Clinical Studies
Here are some highlights from a few Clinical Studies using Proteolytic Enzymes such as Joint-Zyme™:
"A double-blind placebo-controlled study of 44 individuals with sports-related ankle injuries found that treatment with proteolytic enzymes resulted in faster healing and reduced the time away from training by about 50%."
Baumuller M. The application of hydrolytic enzymes in blunt wounds to the soft tissue and distortion of the ankle joint: a double blind clinical trial (Translated from German). Allgemeinmedizin. 1990;19:178-182.
"A double-blind placebo-controlled trial of 71 individuals with finger fractures found that treatment with proteolytic enzymes significantly improved recovery."
Shaw PC. The use of a trypsin-chymotrypsin formulation in fractures of the hand. Br. J Clin Pract. 1969;23:25-26
"Since orally administered enzymes have very few undesirable side effects, this treatment is suitable for all patients with sciatica due to intervertebral disc herniation. The clinical benefit is presumably due to decrease of inflammatory edema in the nerve root and, in suitable cases, clinical results have been spectacularly good."
Treatment of Sciatica due to Intervertebral Disc Herniation, Rheumatology and Physical Medicine, Vol. Xi, No. 1, 1971
"Oral Enzymes accelerate healing".
Oral Proteolytic enzymes in the treatment of Athletic Injuries: A Double Blind Study, The Pennsylvania Medical Journal, October, 1965.
"This double-blind study investigated the use of enzymes in ankle joint injuries. The enzyme group experienced faster reduction of swelling, faster return to joint mobility, and decreased pain during resting or movement compared to the placebo group. The time during which patients were unable to work or train was significantly shorter (reduced by some 50%) with enzyme therapy.
Marcel Baumuller, "Therapy of Ankle joint Distortions with Hydrolytic Enzymes; Results of Double-Blind Clinical Trials," Allgemeinmedizin 19;178-182 (1990).
"An eight-week, double-blind study of 424 patients. Proteolytic enzymes proved particularly effective in alleviating pain, improving mobility, and reducing soft tissue swelling and muscle stiffness.
Klaus Uffelmann, "Enzyme treatment of soft tissue rheumatism," from lecture, First International Conference on Systemic Enzyme Therapy. Univ. of Klagenfurt, Klagenfurt, Austria. September 12, 1990.
"The results indicate that enzyme therapy minimizes the edema so frequently seen following hand surgery." In the group treated with enzymes, 21 our of 25 (84%) patients were considered symptom free on the 7th postoperative day. In the placebo treated group only 4 of 29 (14%) were symptom free. This was a randomized, double-blind study.
Therapeutic Value of Oral Proteolytic Enzymes Following hand Surgery, Archives of Surgery, January, 1969.
"A sixteen patient double-blind, placebo-controlled study of oral surgery patients showed bromelain concentrate significantly reduced the degree and duration of both swelling and pain.
"A Double-Blind Crossover Study of a Pant Proteolytic Enzyme in Oral Surgery", Tassman, Gustav C., D.D.S., et al, Journal of Dental Medicine, April, 1956;20(2):51-53
"This double-blind study of patients sustaining sports injuries found considerable less bruising, reduced swelling, a quicker return to function and fitness to resume play in the proteolytic enzyme treated group.
The Use of Proteolytic Enzymes in Sporting Injuries, S.A. Medical Journal, Feb., 1971
"A preparation containing trypsin and chymotrypsin was tested on professional football players. "two separately conducted double-blind trials have confirmed the value of proteolytic enzyme therapy in resolving inflammation and associated edema and increasing recovery rates. The overall reduction in recovery time is 1.3 days for hematoma and 2.4 days for sprains Ð an approximate 27% decrease in recovery time."
The British Journal of Clinical Practice, September, 1970
"Supplementation of bromelain prior to surgery reduced the average number of days for complete reduction of pain from 3.5 to 1.5, and disappearance of inflammation from 6.9 to 2.0 days, as compared with controls.
Tassman GC, Zafi-an JN, Zayon GM. Evaluation of a plant proteolytic enzyme for the control of inflammation and pain. J Dent Med 1964;19:73-77.